Cranford Hospice is Hawke's Bay's leading palliative care provider. Our dedicated team is available 24 hours a day, seven days a week.
---------------------------
AXA
axaglobalhealthcare.com
Go further with international health insurance. Global support for people who think a little bigger
---------------------------
APOLLONIO
apollonion.com
The Apollonion Private Hospital is an ultra-modern Hospital purposely built to offer the best medical care to its patients.
---------------------------
Durbin
durbinglobal.com
Specialist medical suppliers in sourcing and distributing pharmaceuticals, medical equipment and consumable supplies.
---------------------------
Self
self.com
Women Magazine on Fitness, Health, Food, Beauty & more.
---------------------------
Easyway
allencarr.com
Allen Carr Easyway International operates clinics in more than 150 cities in over 50 countries worldwide.
---------------------------
id Hospital
idhospital.com
All kinds of plastic surgeries at affordable cost.
---------------------------
Al Zahra Hospital
alzahra.com
Al Zahra Hospital Sharjah is the first and the largest private general hospital in the UAE with both inpatient and outpatient treatment at an international standard,
---------------------------
Kunming Children�s Hospital
crhealthcare.com.hk
Kunming Children Hospital integrates first aid, medical treatment, rehabilitation, health care, & scientific research.
---------------------------
UT Health
uthealtheasttexas.com
UT Health East Texas is passionate about delivering the highest quality care with unmatched compassion, outstanding service and innovative technology.
---------------------------
WORLD HOSPITAL DIRECTORY
Dentistry Medical European Journal of Orthodontics - current issue
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Objective</div>Molar distalization is a therapeutic approach commonly used for treating Class II malocclusions. However, the extended duration of this treatment often leads to its replacement with alternative methods that offer shorter treatment times. Micro-osteoperforation (MOP) has been introduced as a technique aimed at accelerating tooth movement and reducing treatment duration. The purpose of this study is to evaluate the impact of MOP on molar distalization outcomes to provide evidence for its effective and safe use.<div class="boxTitle">Search methods</div>A comprehensive search was conducted across multiple databases, including MEDLINE, Web of Science, EMBASE, Scopus, and Cochrane’s CENTRAL, up to April 2024, without any language or date restrictions.<div class="boxTitle">Selection criteria</div>Only randomized clinical trials (RCTs) that addressed the defined PICO question were included in the analysis. The risk of bias in the included studies was assessed using the Cochrane Risk of Bias 2.0 (RoB 2) tool.<div class="boxTitle">Data collection and analysis</div>Relevant data were extracted using custom-designed forms, and a random-effects inverse variance meta-analysis was performed to synthesize the results. The primary outcomes analyzed were the rate and amount of molar distalization, while secondary outcomes included pain levels, root resorption, and periodontal health.<div class="boxTitle">Results</div>Four RCTs, involving a total of 71 participants, were included in this exploratory review. Most studies were at low or some concerns risk of bias. The meta-analysis revealed no significant differences in the rate or amount of molar distalization between the MOP and control groups (mean difference [MD] = 0.1 mm/month and 0.01 mm, respectively, <span style="font-style:italic;">P</span> > .05). However, the MOP group reported significantly higher pain levels on the day of the procedure (MD = 2, <span style="font-style:italic;">P</span> = .01) on a 10-point visual analog scale (VAS) compared to the control group. This difference in pain perception was no longer significant seven days after the procedure (MD = 0.52, <span style="font-style:italic;">P</span> = .52).<div class="boxTitle">Conclusion</div>While MOP is associated with increased immediate postoperative pain, it does not significantly enhance the efficiency of molar distalization. Therefore, the use of MOP for distalization should be judiciously considered and reserved for cases that involve particularly challenging or prolonged movements, based on the specific needs and characteristics of each patient. Limitations of this review include the small number of available RCTs and variability in MOP protocols, which may limit the generalizability of the findings.<div class="boxTitle">Registration</div>The protocol for this systematic review was registered at PROSPERO with the ID CRD42024589482</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Objectives</div>The aim of the study was to determine the genetic and environmental effects on transverse growth of craniofacial structures, within and between identical and fraternal twins.<div class="boxTitle">Methods</div>The sample consisted of 142 children in total, divided into 29 pairs of monozygotic twins, 42 pairs of dizygotic twins, and 1 set of dizygotic triplets. Postero-anterior cephalometric radiographs were taken at the ages of 9, 12, and 15 years. Intercanine width, maxillary width, mandibular width, nasal width, and facial width variables were measured. The genetic and environmental components of variance were analyzed with structural equation modeling for multilevel mixed effects.<div class="boxTitle">Results</div>Intercanine width was initially mainly characterized by a moderate genetic component at 9 years (53%), with environmental influence increasing at age 12 (36%) and peaking at 15 years (84%). Maxillary width was under strong genetic influence at 9 years (70%), with genetic influence remaining strong up to 15 years (73%). Mandibular width was under additive genetic influence at 9 years (76%), with dominant genetic influence remaining high at 15 years (81%). Nasal width was under strong additive genetic influence at 9 years (69%) but switched to increased environmental influence at 15 years (59%). Finally, facial width had a moderate genetic influence at 9 years (66%), which increased at 15 years (90%).<div class="boxTitle">Limitations</div>This study included patients of European descent, which may limit the generalizability of the findings to other ethnic groups.<div class="boxTitle">Conclusions</div>Although monozygotic and dizygotic twins share at least part of their genetic material, environmental factors accounted for about 10%–84% of variability at various ages, with intercanine width being most affected.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Introduction</div>B-cell lymphoma 6 (Bcl6) inhibits osteoclast differentiation <span style="font-style:italic;">in vitro</span>; however, its role in orthodontic tooth movement (OTM) remains unclear. This study aimed to investigate the role of Bcl6 in OTM of rat molars.<div class="boxTitle">Materials and methods</div>OTM was performed on the maxillary first molars of male rats using nickel-titanium coil springs (25 gf) for 14 days with or without local injection of FX1 (50 mg/kg), a Bcl6 inhibitor (n = 10 per group). Micro-computed tomography (CT) images were used to analyse OTM distance and bone morphometric parameters. Immunohistochemistry (IHC) determined Bcl6 expression and tartrate-resistant acid phosphatase staining (TRAP) staining assessed osteoclast differentiation. TRAP staining, and reverse transcription-quantitative polymerase chain reaction determined the effect of FX1 (1 μM) on <span style="font-style:italic;">in vitro</span> rat osteoclast differentiation. The effect of FX1 on cell proliferation and Smad4 expression in periodontal ligament (PDL) cells was determined.<div class="boxTitle">Results</div>Administration of FX1 significantly increased OTM distance and decreased the bone/tissue volume compared with vehicle treatment. IHC staining showed that the vehicle-OTM group had higher expression of Bcl6 than the FX1-OTM group. The number of osteoclasts on the compression side was significantly higher in the FX1-OTM group than that in the vehicle-OTM group. FX1 enhanced osteoclast differentiation and expression of <span style="font-style:italic;">Nfatc1, Dc-stamp,</span> and <span style="font-style:italic;">Ctsk</span> mRNA in osteoclasts <span style="font-style:italic;">in vitro</span>. FX1 significantly promotes PDL cell proliferation <span style="font-style:italic;">in vivo</span> and <span style="font-style:italic;">in vitro</span>.<div class="boxTitle">Limitations</div>We evaluated only 14 days of OTM.<div class="boxTitle">Conclusions</div>Bcl6 may play an important role in OTM <span style="font-style:italic;">via</span> modulation of osteoclast differentiation and PDL cell proliferation.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Background/Objectives</div>Mandibular second molar (MdM2) is often lost, and its space is filled with a bridge or implant. MdM2 extraction followed by orthodontic treatment protracting mandibular third molar (MdM3) towards the MdM2 position may overcome the missing of MdM2. The objectives of our study were to describe the outcome of the procedure and examined clinical risk factors such as external apical root resorption (EARR) and alveolar bone loss (ABL), as the indicators of poor orthodontic treatment outcomes.<div class="boxTitle">Materials/Methods</div>This retrospective study included 70 cases in 56 patients who received orthodontic treatment at Tokyo Medical and Dental University Hospital between 2007 and 2018. Multi-bracket appliances were used in all patients for MdM3 protraction. Using linear mixed effects models, EARR and ABL were regressed on various factors, including panoramic and cephalometric variables.<div class="boxTitle">Results</div>With the mean treatment duration of 1040.4 ± 441.8 days, MdM2 space closure was achieved in 92.8% (65 cases). The ANB angle (<span style="font-style:italic;">P</span> = .023) and the use of temporary anchorage devices (TADs) (<span style="font-style:italic;">P</span> = .021) were significantly associated with the greater EARR, while the mandibular plane angle (<span style="font-style:italic;">P</span> = .033) was associated with the greater ABL. MdM3 protraction using the fixed appliances resulted in the closure of MdM2 space in > 90% of cases without evident root resorption.<div class="boxTitle">Limitation</div>There is a possibility of residual confounding due to the nature of observational study.<div class="boxTitle">Conclusion/Implication</div>Orthodontic treatment of MdM3 protraction may be a feasible strategy to close the space of the missing MdM2.</span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Objective</div>This prospective controlled study aimed to assess whether changes in mandibular incisor inclination during orthodontic treatment with fixed appliances affect gingival thickness (GT) and the width of keratinized gingiva (WKG), and having as reference an untreated group of participants.<div class="boxTitle">Materials and methods</div>Forty consecutively recruited adult orthodontic patients and 40 untreated volunteers, matched for age and gender and selected from the same background population serving as controls, were included. Mandibular incisor inclination was measured in lateral cephalograms before treatment commencement (T0) and 1 month before fixed appliances’ removal (T1). Gingival thickness was measured using an Ultrasound Device (US) and width of keratinized gingiva (WKG) using a standard periodontal probe within the frames of a full periodontal examination at T0, T1, and 1 year after bracket removal (T2), that is, at about 30 months from T1.<div class="boxTitle">Results</div>Nineteen females and 21 males in each group [mean age in years (range): intervention group 23.1 (16.8–43.3); control: 21.85 (18.2–43.9)] were analysed. Overall, change in incisor proclination [mean change in Incisor Mandibular Angle Plane—IMPA (ΔIMPA) was 6.35° (SD 5.08°)] was not associated with any significant change in soft tissue thickness and with alterations in WKG. The group receiving fixed appliances did not exhibit thickening or thinning of GT in comparison to the control group; the WKG was reduced in the intervention group in comparison to the untreated group, where it essentially remained unchanged (#41: coeff.: −0.29, <span style="font-style:italic;">P</span> value: .1, 95% CIs: −0.65, 0.06; #31: coeff.: −0.51, <span style="font-style:italic;">P</span> value: .01, 95% CIs: −0.88, −0.14).<div class="boxTitle">Conclusions</div>Lower incisor proclination during orthodontic treatment does not appear to significantly alter GT and WKG, but orthodontic treatment, overall, leads to reduction of the WKG.</span>
Home
Contact
Back to "Medical Updates - Homepage"
